Bioelectronic Sensor mesh could grow with Heart Tissue.

[{"selector":"#anim-a5fa81c0-749e-49fe-a9d7-425e2d97f97e","keyframes":{"transform":["scale(1)","scale(1.01)","scale(0.999)","scale(1)"],"offset":[0,0.33,0.66,1]},"delay":0,"duration":3000,"easing":"ease-in-out","fill":"both","iterations":1}] Researchers at UMass Amherst's college of engineering are working on cardiac micro-tissue, grown from human stem cells, which replicates the mechanical and electrical activity of the heart.

Traditional methods of monitoring cardiac tissue involve inserting sensors after growth, which can damage the tissue. Hence, there's a need to grow tissue on pre-existing sensor matrices.

The experiment aims to monitor "excitation-contraction coupling" by measuring both the self-generated electrical stimulus and resulting movement in the tissue.

The team designed graphene transistors, roughly the size of a cell, to sense electrical potentials and mechanical movement simultaneously.

Graphene's thinness allows it to detect even the smallest muscle contractions without impeding the heart's function.

These graphene transistors are interconnected by a mesh of gold palladium conductors on a flexible substrate, providing flexibility and stretchability.

The conductors' serpentine design ensures flexibility and stretchability, creating a soft, stretchable porous mesh scaffold similar to human tissue.

This innovative approach allows for non-invasive monitoring of cardiac micro-tissue throughout its maturation process, as graphene can withstand biological environments without degradation.

The research represents a significant advancement in cardiac tissue monitoring, potentially leading to better understanding and treatment of heart-related conditions.

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